we're doing somthing like this in a couple of weeks... 33 out of ojai... if it's still cool inland wind over to 58 and take that to 229, go north on 229, and then west to cambria, north from there on pch... might need to take nacemiento road due to the slide mentioned above, then go north to carmel valley road into carmel.... if hot inland, then just head for the coast on 166 after doing 33 out of ojai
hwy 1 is mostly great, sometimes just okay north from there all the way to fortuna.... from fortuna you could take 36 east to lassen park, then south on 89... make sure to do bucks lake road from quincy down toward lake oroville, then back to 89 on laporte road or 49... south past tahoe and on to ebbetts, monitor and sonora passes... into yosemite on tioga pass.... and homeward.... what a trip...
if you do hwy 1, try to get out early in the am and avoid it on weekends if possible... lots of tourist traffic
you'll want to check the sierra passes at the site mentioned by madmike to see whether they're open... lots of snow this year