Missed this thread for a while. I live in WV. Rt 33 and 250 offer some nice options. But, there is one road that no one has mentioned that is among the finest anywhere in the East. Rt 15 from Webster Springs to Valley Head is a don't miss this or you will kick yourself hands down choice. If I understand correctly, you are coming into WV near Huntington. Suggest taking I64 slab to Charleston, then Rt 60 E (Midland Trail - read historic, scenic and mtn twisty to Charmco - w/ possible tourist stop detour South 19 15 miles to New River Gorge Bridge). Rt 20 north to Webster Springs (via Fenwick and Craigsville) and then Rt 15 N out of Wesbster Springs. It dumps out onto 219 at Valley Head, about midways of the state, so you can go either N or S in the mountains. To the north is 250 and the smoke hole country (Parsons, Davis, Canaan Valley ain't to shabby either). To the south, are Snowshoe mtn, Rt 150 - not so much twisty, but fantastic mtn scenery - and Rt 39 or the rest of 219 S. If you choose north, Elkins has several places to stay and eat. To the south, Lewisburg is among the best kept secrets around for generally smoosing about - from which 219 S to Bluefield and 52 N back to Huntington area is good ride. It's WV follow your nose, you can't go wrong.
Happy trails,
Jim
