Using Ethanol in your fuel will result in reduced miles per gallon (mpg) as the "energy" value of ethanol is less than that of petrol. Ergo, the more ethanol in the fuel, the fewer miles per gallon. Depending on your vehicle and driving style, it could be more costly, mpg-wise, to use the "cheaper" fuels blended with ethanol.
As to the use of ethanol. Nearly all motorcycles, and a large percentage of other vehicles, will sustain some form of damage, usually to fuel systems, when using more than a 10% ethanol mix. If you have a veteran or vintage vehicle, unless it's been converted (highly unlikely), any ethanol in the fuel will cause damage to the fuel system.
My 2019 FJR is rated for E10 according to the manual, but I will rarely use a fuel blend of more than 5% ethanol as it actually costs me more per mile (your mileage may vary so check for yourself). I would never, ever, use a fuel blend of more than 10% ethanol and will only use E10 when E5 or "E0" is not available.
For balance. My "commuter" motorcycle, not a Yamaha, is 12 years old. I bought her new and have covered 121,200 miles (~195,000 km). I have only ever used supermarket E5 in her and I have had no problems so far (famous last words) with the fuel system.
Although it is easy to remove ethanol from fuel, I wouldn't recommend it as, apart from the obvious dangers (fire etc.), there are some other caveats (octane rating being one).