I am not familiar with Pirellis whatsoever......
However, obviously one of the major advantages to balancing our own tires is that we can balance the wheel all by itself and figure out not only where the heavy spot is, but also by how much.
For instance, I have my rear wheel marked where the heavy spot is, and it takes 28g to balance the wheel only. The last time I installed a rear Avon (Unfortunately no mark for heavy spot), and first tried to balance the wheel/tire combo, the heavy spot was almost exactly identical to where it was with the wheel only. And it was going to take more than 60g to balance. So obviously, through sheer bad luck, I had matched the heavy spot on the wheel and tire.
So even though its a pain in the arse, I deflated the tire, re-broke the beads, and rotated the tire relative to the rim by 180 degrees. After getting the tire re-seated and aired up, Voila!.........
It now took only 4g (half a sticky weight) to balance the whole rear combo, and it was dead on!
Schwing!
Too bad I got a flat 125 miles later, but thats for another bedtime story boys and girls.
IMHO, 21g is not that bad, but then I have been known to be a wee bit too anal-retentive.
Did you balance your wheel only and know that info already? If not, I would probably go with what you have, and assuming no problems, do it the SkooterG anal-retentive "right" way the next time.