I carry a notebook/laptop everyday for work on the FJR, sometimes a couple hundred miles per day. I made a 7,000-mile trip carrying the laptop last year. Here's a thought or two...
Size might not matter, but shape sure does. I have a Yami top bag and not many laptops fit well inside of it. The Givi 52 has better internal dimensions for laptops. I have one of the nearly tiny Dell D410 laptops, yet there's no way to fit it inside the side bags with any reasonable padding.
Be prepared to shop around for cases. I find one that provides moderate padding with minimal side pockets etc. to be most useful on the bike. The case I'm currently using is a Targus brand with the rubber feet removed. The feet chew away on the inside surface of the top bag over time, and they waste a lot of space. The case that works best for regular transport of your notebook may not be the case of choice for transport on the bike. Buy a cheap one for the bike, rip it up and make it fit well.
Pack your AC adapter and other accessories separate from the laptop. There's loads of vibration and contents shifting on long rides. Don't ever expect anything to be where you originally packed it. You'd be amazed at how much damage the prongs of an AC cord can do during the course of a single day's 600-mile journey, rubbing against the laptop shell. Make sure you don't pack any liquids in the same bag/case as the laptop. Pack your infrequently used but must-go clothing around the laptop (raingear, extra gloves, neck wrap etc.). It makes the best use of space and you won't be forced to remove the laptop you just packed to get at clean underwear. I just can't bring myself to pack my dirty underwear around the laptop.
Aircards are your friend. Internet access is simply not available in many of the places we stop. It improves your odds a lot to have an aircard Internet service.
SD cards are your best friend. A single 4GB SD memory card holds a lot of pictures and route files. Preprint some stamped envelopes and pack a few SD cards. Copy your latest pictures and mail it home. Copy your pictures and route files to an SD card that you keep on your person for backup. You have to worry about more than physical damage to the laptop and camera. You have to worry about somebody stealing your stuff from a hotel or campsite. While insurance may cover the equipment loss, it won't cover the loss of memories.
Lastly, good luck with getting the GF/SO to leave her extra shoes behind so that you can pack the laptop. You should see the expression on her face when I say, "Well dear, it looks like once again it's you or the laptop."