Rode thru there last fall, head east towards Van Buren on 60, not crazy about 60, but gets you to Van Buren. Visit Big Springs just south of VB, then head back north up to VB, take state route D out north up to 21 north, to 106 West to Alley Springs. For a day ride, head back south on 19 (great riding), and stay on 19 to 160, then head back west to West Plains and back to Mountain Grove.
The Springs were really nice to visit, and impressive. Some locals can give you better and more complete info, but as long as you stay in the Ozarks, don't think you will have a bad ride.