I prefer
Microsoft Streets & Trips 2006
Picked it up at Fry's for $9, after a $20 MIR (2006 version)
This was not an upgrade version, full version, full $20 rebate, no pre-qualification
I have also seen Staples & Office Depot sell it for $19 after rebate.
Amazon has it for $35 right now (no rebate) so it is still fairly cheap.
I have used 2003, 2004 & 2005.
Not much of a difference between 2005 & 2006 (each version just adds more roads, updates street names, improves accuracy, etc...)
No earth shattering technical updates between years that I tend to notice (outside USB GPS interface-which I don't use)
It is really easy to use and makes a good set of maps with printable directions.
Turn by Turn, mileage to next stop, trip total cost (you enter MPG, cost of gas, etc..)
It also has a pretty accurate feed to the latest construction data (requires internet access)
Search function within x number of miles (gas, food, golf courses, hotels, etc...)
Really handy stuff
They also sell a version that comes with a GPS unit (USB to a laptop or maybe a PDA)
I have tried it but prefer the Delorme unit.
Both are fine beginer GPS units for a car, no use on a motorcycle though.
That is my .02, I use Streets & Trips 2006 for 90% of my at home pre-trip planning.
Once on the road I use a Garmin etrex or my new Garmin 2730 (motorcycle)
Usually have the laptop in the car (out of town trips)