It could, but won't be as easy.
I have a TwinMax electronic vacuum differential meter that I bought when I owned a BMW oil-head, which I imagine is pretty similar to the Harmonizer. Here's how I would go about it:
1) Close down all 4 air screws fully to lightly seated. You will have to slightly hold the throttle open to get the engine to idle with the air bypass screws all the way in. Use a throttle lock or a ty-wrap around the throttle and brake lever to hold the throttle.
2) Hook the meter up to ports for #2 and #3 (caps on the unused ports) and balance those two with the linkage screw between them. Because you can only access the adjustment screw with the throttle held wide open, you'll have to make this iterative adjustment stopping the engine to adjust, and restarting the engine to check vacuum.
3) Move the meter hoses to ports #3 and #4 and balance them with the linkage screw while engine is running.
4) Move the meter hoses to ports #1 and #2 and balance them with the linkage screw while engine is running.
5) Open all 4 air screws the same amount and remove the throttle lock. 3/4 turn each is a good starting point. If the idle speed seems a bit too low open them all an additional 1/4 turn each.
6) Once you are happy with the idle speed, sync each of the other three cylinders to the #3 as a reference one at a time, moving the vacuum hoses, adjusting the air screws of that cylinder. .