Thanks for the replies. I thought about spots and it's propably the way to go. My bike does not have risers and the bars are set back all the way. Before, when I needed a clearer view behind me I could move my arm in a little and I could see. I thought it could be a problem because the Gen II mirrors do block some air to the hands by themselves so they are in the line of sight. I also think how much the guards are in the way would vary by rider and what angle you set the levers.
I did do a search and wondered why on a recent post asking for Any Problems with VStrom Guards nobody mentioned this, so I thought it was a good new post.
I would not consider changing stock mirrors, they worked great until now so I would take the guards off first. I'll try to find a way to make it work for me for the 4 months of winter. After that, they would come off anyway, a 5 minute task.
On another note, I had a '96 Royal Star and which I put on National Cycle hand guards. They worked great and were dark tinted clear plastic. Anyone who also rides a cruiser with a police style shield I would recommend those for cool weather.