Ross, I had a detailed reply and lost it. The route looks great but I have a couple suggestions.
Make a waypoint for Mt. Mitchell along the BRP in Burnsville, NC. It's easy to miss off the Pkwy and it's worth having the waypoint. Beware of the speed limit on this road enforced by the state park. It is lower than the BRP and don't ask how I know.
After Deals Gap you have a waypoint on the Cherohala Skyway, but your route follows rt 81 north of the Skyway. Be sure to drag the route back to Cherohala hwy 143.
Out of Tellico Plains you make a Beeline for I-40 via I-75. Move your waypoint south on the Natchez Trace to US-64 and take secondary roads instead. It's actually less time, more scenic, and you don't want to be on I-40 with all the trucks in that section. You're staying on the Natchez Trace to Tupelo, MS then heading west to Clarksdale and north to I-40 at Brinkley. A local might have better suggestions.
You then take I-40 to Little Rock and cut southwest on US270 to Mt Ida, heading north on US71 to I-40 at Ft. Smith. Again a local probably has good ideas. I-40 to Okalhoma City, then US 270 NW to US-50 on the KS-CO border.
In Colorado, the route is pure genius with one exception. As you head to Mt Evans, you head northeast from Hwy 9 on US 285 towards Denver. Stay on Hwy 9 towards Dillon, then take US-6 over Loveland Pass and pickup I-70 East to Mt. Evans. It gives you 2 extra passes and a lot of great scenery the other route does not have.
The Peak to Peak Hwy to Estes Park, then Trail Ridge to US 40 at Granby and all the stuff through Leadville, Aspen, Ouray, Durango and Mesa Verde is nothing less than amazing. Have fun!
From Mesa Verde you take US 160 to Kayenta and head north to Monument Valley and Mexican Hat. The route then move north on 261 to UT 95 and Glen Canyon. WARNING! There is nothing out here and your gas tank is going to look small. Out of Mexican Hat, take 163 just 1/2 mile northeast and get gas at the Shell station. Failure to leave Mexican Hat without a full tank of gas could leave you stranded. Put in a Gas Stop on your route and don't forget. Your selected route UT-261 is an unpaved road north of Moki Dugway. The FJR can take the road, but if you're not comfortable on this kind of road, stay on 163 towards Blanding. Lots of ADV riders like 261.
I'll pick this up later.