That is roughly my plan for the trip down this year too. We're planning on taking 3 days to get there from here (Southern NH) and using minimal Interstates. I'm planning on heading westward and then right through Shandanken! to get thru the Cats and down Rte 30 (of course) with a first night layover somewhere near loverly Scranton. Second Day we'll layover in Elkins, then third day down the remainder of 219 (can't get enough of that road) and arrive in Henderson, NC on Thursday the 20th.
Anyone wanting to tag along with that basic itinerary is welcome to join us. Or propose a better one!
FWIW - The Days Inn in Elkins used to be the town's hospital which has (barely) been converted into a hotel. The rooms are tiny, as you would expect in a hospital, and a little bit creepy, but it's comfortable enough and cheap. They do have a restaurant attached, somewhere in the basement, that has a liquor license. However nobody there even knew how to make a martini. Better stick with beer! There's also a breakfast type restaurant out back if you want more than the continental breakfast.
On another trip we stayed at the Holiday Inn Express, which was considerably nicer, but more expensive. There is a great pub a few blocks walk from the hotel for dinner and libations.