I have the Alaska leather cover. Love it. Keeps heat away, absorbs butt moisture, and provides a little better weight distribution.
It's not a replacement for a custom seat, but seems to work for me for long rides.
FWWI, I would experience butt burn about 250 miles into a day trip on the highway before the sheepskin. Much less on twisty roads where you are shifting weight in performance mode.
Now I do not experience butt burn at all and am not considering an aftermarket seat anymore. Granted, I do not Iron Butt. 350 miles of twisties is about where I want to stop, but still no butt burn.
Last month with the pad I went 2600 miles in 6 days (mix of slab and mountain riding)...no butt burn. Temps were mix of very hot/humid, rain, and Canada morning chills (ie all heated gear at full blast). I've had it about 2 years/11K miles and have never even considered taking it off on my 03 (read seat well broken in).
Same riding gear (aerostitch). Same gold bond powder treatment in the am and after lunch. Same mesh riding shorts before and after the swap. The latter two are definitely advisable regardless of seat, however the gold bond may be sensitive to your wifes' privates. Dunno.
Net..Net...she will not know if she likes it unless she tries it. But I will say it's 10000x better than beads and 10x better than nothing.
I'm confident a custom seat would be better, but it may be worth the $500+ difference to give it a chance, especially if you guys are not touring nuts.