End of the road for my '05 at 144,682 miles.
Prius driver didn't want to share lanes. Fortunately, she was only doing about 10 mph and I was only doing about 20 mph, but still got my very first ambulance ride and CT scan as I had what looked like a compound fracture of my right thumb (turned out to be dislocated, but when one's thumbnail touches the back of the next joint, bone ends are visible through the torn skin - fooled both me and the good Samaritan RN who pulled up to help). I was wearing good gloves, the glove's knuckles on the left hand were heavily scraped, and that hand was fine. I also stopped sliding when my shoulder and helmet hit a curb and impact was close enough to my neck they wanted to make sure there were no spinal complications (none found, thankfully). Motoport/Cycleport gear did its job - not a scratch, but a few deeply bruised / sore spots from impact and/or flailing.
Ripped the front bumper off the Prius - I'm not a forensics guy by any means, but from looking at the damage to the bike, main point of impact was probably near the marker light on the fairing, with paint transfer both fore and aft of that point. No idea how my right lower leg (knee to foot) came out unscathed as the brake pedal was also bent. I figure my body must have been about even with her front door post/ front fender when she initiated her illegal lane change (crossing solid lines to get into a merging on-ramp lane) and front wheel just past the front of her car by the time she hit me. Haven't seen the police report yet, but if it comes out as anything but 100% her fault, I'm going to be surprised and disappointed
Progressive totaled the bike, including paying for aftermarket stuff, and paid for my gloves and helmet. Excellent service thus far, we'll see how it goes once they and the Prius driver's insurance start tussling over ambulance and medical costs.