Only saw one Toy reference here... While it's not a pickup... I have a 2002 Toyota Sequoia, bought it off eBay about this time of year in 2008 from NJ for 10K, book was 15k. It had 88,000 on it. I stole it. The Toy fullsize of the same vintage is similar in many ways (except for leaf springs in the rear where mine has coils)
It now has over 135,000 on it... i have done nothing but regular maintenance to it, and the brakes once when i got it, then rears a month ago (just pads)
I did the timing belt, tensioner and WP, at 90k (I am assuming the dealer scared the guy i bought it from... thats why the deal?) as regular maintenance. When i did this.. i checked valve clearances. there was one valve that was .001 off the center of the specs(fine).. the other 31 were dead center.. perfect.
I literally drive it and change the oil once in a while... it has been truly amazing. No interior problems.. nothing (and it has a LOT of **** that could break...it just doesnt)
Oh...add a tailgate handle i replaced...
My neighbor who has a 2001 fullsize Toy Pickup, just had his frame replaced, by toyota, for free, with 125,000 on it. Toyota charged him nothing... he bought it used... they took care of it. Now.. I dont think the frame should have rotted... but they do around here..Ford and Chevy too... But I havent heard of them replacing any for free... my frame looks fine (maybe the NJ / NY difference in road treatments?)
I got a recall notice in the mail... offering to replace my frame at no charge, or refinish the frame with some kind of rust inhibitive coating if it has no perforations.(it is fine...) Pretty decent of them...
They hold thier values well, Toy might be worth a look.
If it must be domestic... and if we are voting... Ford.. hands down. (I own a Ranger with 267,000 miles on it.. it is driven daily by a 17 year old girl and is great) I have had lots of Fords.. been great.. I grew up a Bowtie fan... and was one, until I started buying new ones... Loved my Impala... it was a piece of ****, Hated my wifes Equinox...very nice utility features, comfy, fun to drive in nice weather...but the 4X sucked(I'd call it dangerous), and it had a lot of electrical issues. And.. the dealer SUCKED.. that didnt help.