Started doing some mapping, thinking about the ride from Houston to Reno... probably looking at 2100 miles 1-way at least. The boring way would be to slab it on I-10 to Californication, then head north... or, possibly go through Austin, Abilene, towards Santa Fe, Durango, head north to Grand Junction, then go west on I-70... and eventually getting to Reno via Hwy 50. As previously mentioned, the treck across Utah and Nevada might be better done at night... although I don't know if the vacation gods have that much to give.
Just some initial thoughts...